Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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1. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is often an impurity related to bortezomib, a proteasome inhibitor used in the remedy of several myeloma. Its synthesis or examine is essential for making sure the purity and basic safety from the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor in the synthesis of abiraterone acetate, a drug Utilized in the treatment method of prostate most cancers by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-ten-1): A key compound from the synthesis of imatinib, a drug that targets distinct varieties of cancer, which include Persistent myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats different cancers such as breast, lung, and prostate cancer.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): These are intermediates from the synthesis of gemcitabine, an anti-cancer drug. Their review is important for optimizing the output method and making sure higher purity.
Lapatinib Intermediate (CAS NO. 231278-eighty four-five): Lapatinib is utilized to deal with breast most cancers, and these intermediates are involved with its production.
Fulvestrant Intermediates: Fulvestrant is really an estrogen receptor antagonist Utilized in the therapy of breast cancer. Many intermediates help in the synthesis of the drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-sixteen-nine): This Afatinib-1 intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug powerful in dealing with cancers like ovarian, breast, and lung cancer.
three. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug Employed in the procedure of colorectal cancer and modest mobile lung most cancers.
three-Amino-one-hydroxyadamantane (CAS 702-82-nine): This compound is involved in the synthesis of adamantane derivatives, which have numerous programs, like antiviral Homes.
Vildagliptin Intermediates: Employed in the creation of vildagliptin, an oral drug for variety 2 diabetes that inhibits the enzyme DPP-4 to regulate blood sugar amounts.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-48-one): This compound is linked to the synthesis of assorted gluconic acid derivatives, which are 16-dien-3beta-ol 3-acetate Employed in food stuff, pharmaceutical, and industrial purposes.
Canagliflozin Intermediate 2: A precursor during the synthesis of canagliflozin, a medication utilized to manage kind two diabetic issues by inhibiting sodium-glucose co-transporter 2 (SGLT2).